Freezing of gait in people with Parkinson's disease (PwP) is associated with executive dysfunction and motor preparation deficits. We have recently shown that electrophysiological markers of motor preparation, rather than decision-making, …
During navigation of complex environments, the brain must continuously adapt to both external demands, such as fluctuating sensory inputs, and internal demands, such as engagement in a cognitively demanding task. Previous studies have demonstrated …
Advancements in acquisition technology and signal-processing techniques have spurred numerous recent investi- gations on the electro-cortical signals generated during whole-body motion. This approach, termed Mobile Brain/ Body Imaging (MoBI), has the …
Objective: Freezing of gait (FOG) is a brief, episodic phenomenon affecting over half of people with Parkinson’s disease (PD) and leads to significant morbidity. The pathophysiology of FOG remains poorly understood but is associated with deficits in …
An emerging neuropathological theory of Autism, referred to here as the neural unreliability thesis, proposes greater varability in moment-to-moment cortical representation of environmental events, such that the system shows general instability in …
Visuospatial memory describes our ability to temporarily store and manipulate visual and spatial information and is employed for a wide variety of complex cognitive tasks. Here a visuospatial learning task requiring fine motor control is employed to …
Neurophysiological investigations in patients with schizophrenia consistently show early sensory processing deficits in the visual system. Importantly, comparable sensory deficits have also been established in healthy first-degree biological …
Young children are often hyperreactive to somatosensory inputs hardly noticed by adults, as exemplified by irritation to seams or labels in clothing. The neurodevelopmental mechanisms underlying changes in sensory reactivity are not well understood. …
When sensory inputs are presented serially, response amplitudes to stimulus repetitions generally decrease as a function of presentation rate, diminishing rapidly as inter-stimulus intervals (ISIs) fall below 1 s. This ‘adaptation’ is believed to …